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The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey

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So the quality of the herbal remedy or vitamin supplement may be different from bottle to bottle

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In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]